USB

The Axe-Fx II connects to a computer via USB. Pages 22-24 of the manual describe requirements, installation and capabilities.

USB support is Audio Class 2.0 compliant. There's support for:

• Editing and remote control via Axe-Edit (no MIDI interface required).
• Audio communication (no audio interface required, except when using analog audio).
• Use as an exclusive USB-to-MIDI interface for other products (in I/O > MIDI set USB ADAPTER MODE to ON).

Editing and recording can be done simultaneously.

Drivers for Mac and PC which add USB support are available for download here. Ignore the options in the driver's control panel. Source

Notes:

• When monitoring audio using the Axe-Fx II itself there's no latency. When monitoring the audio signal from the computer, latency is determined by the host computer capabilities. Source
• High-pitched noise when using an USB connection may be caused by a ground loop. Cliff: "The USB spec calls for grounding the cable at both ends (mistake). This can create a ground loop. Make sure everything is plugged into the same outlet strip." Source
• If you're recording with an application which uses the system selected input (all 4 channels), you will end up with a recording that contains the dry tracks also. The Axe-Fx II currently doesn't let you mute the dry tracks. Source
• The Axe-Fx II cannot connect to a USB stick. Source

In a DAW the Axe-Fx II appears as a 4-In, 2-Out device.