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Spillover: in the Axe-Fx II owner's manual

Spillover: global on/off switch

Multi Delay and Megatap Delay don’t support spillover.
Spillover may be affected when switching between X/Y states, if drastically different algorithms exist between the two states. For example, if one scene has a Digital Delay and the next scene uses a Tape Delay, spillover will probably not function correctly as these modes use different algorithms.
User: "I have two patches that both has delay blocks disabled and when I switch between these patches via MFC the delay spillover sometimes kicks in really loud." Cliff: "This can happen if you rapidly switch between presets many times. The unit requires a small amount of time between preset changes to clear unused buffer space. This is done as a background task." source

If you use Mix and Level to dial in the effects level, the volume level of the reverb and/or delay trails may change when switching presets. This can be prevented by keeping Mix and Level at fixed values, and using Input Gain to set the desired effects level. source